A Phase 1/1b Study of IAM1363 in HER2 Cancers

This is a Phase 1/1b open-label, multi-center dose escalation and dose optimization study designed to evaluate the safety and preliminary efficacy of IAM1363 in participants with advanced cancers that harbor HER2 alterations.

Trial Details

NCT ID
NCT06253871
Phase
PHASE1
Sponsor
Iambic Therapeutics, Inc
Status
RECRUITING
Cancer Type
Lung Cancer
Interventions
  • IAM1363
Locations (sample)
  • La Jolla, California, United States|32.84727,-117.2742
  • Los Angeles, California, United States|34.05223,-118.24368
  • Aurora, Colorado, United States|39.72943,-104.83192
  • Miami, Florida, United States|25.77427,-80.19366
  • St. Petersburg, Florida, United States|27.77086,-82.67927

Key Eligibility Criteria

  • Age ≥ 18 years
  • Have relapsed/refractory HER2-altered malignancy; for selected cohorts, prospective confirmation of HER2 alteration by central testing is required
  • Have progression of disease after the last systemic therapy, or be intolerant of last systemic therapy
  • Have radiographically measurable disease by RECIST v1.1 and/or RANO-BM

For full eligibility, visit ClinicalTrials.gov.

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