Other Oncogene Mutations for Anti-EGFR Efficacy in Patients With Left-sided RAS-wild Type Metastatic Colorectal Cancer

Patients meeting the inclusion criteria will be randomized 1:1 into Cohort A (n ≈ 177) or Cohort BC (n ≈ 177). Cohort A is the control: patients receive combination chemotherapy with FOLFOX plus anti-EGFR therapy (panitumumab or cetuximab) based on RAS/BRAF wild-type data, according to clinical guidelines. The BC cohort begins FOLFOX chemotherapy and simultaneously undergoes extensive molecular genetic profiling. Further, the BC cohort, depending on the profile, is divided into cohort B - patients without changes in alternative oncogenes, and cohort C - with changes in alternative oncogenes.

Trial Details

NCT ID

NCT06226857

Phase

PHASE3

Sponsor

City Clinical Oncology Hospital No 1

Status

RECRUITING

Cancer Type

Colon Cancer Colorectal Cancer

Interventions

• Cetuximab

Locations (sample)

• Moscow, Russia|55.75204,37.61781
• Moscow, Russia|55.75204,37.61781
• Reutov, Russia|55.76273,37.86303

Key Eligibility Criteria

• Informed consent signed before commencing any procedures related to the clinical trial.
• Age ≥18 years.
• ECOG status 0-2.
• Life expectancy greater than 12 weeks as assessed by the investigator.

For full eligibility, visit ClinicalTrials.gov.

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