TRAIL Study: Feasibility and Pilot

This is a pilot study to compare two ways of managing newly identified thyroid nodules that are likely to be cancerous based on ultrasound result and which under usual care would undergo immediate biopsy. The main goals of this pilot study are 1) compare anxiety at 6 months in each treatment arm using the validated instrument Anxiety-CA, 2) measure thyroid quality of life in each treatment arm Participants will be randomized to one of two groups: 1. immediate biopsy (usual care) 2. Active monitoring (serial ultrasound based monitoring and close clinical follow-up)

Trial Details

NCT ID
NCT06220656
Phase
NA
Sponsor
Dartmouth-Hitchcock Medical Center
Status
RECRUITING
Cancer Type
Medullary Thyroid Cancer
Interventions
  • Biopsy
  • Active Monitoring
Locations (sample)
  • Lebanon, New Hampshire, United States|43.64229,-72.25176

Key Eligibility Criteria

  • Participants must be ≥18 years of age.
  • Participants must be able and willing to provide informed consent or have a surrogate capable of providing same.
  • Participants must be absent of symptoms referable to the nodule: dysphagia or nodule physically visible and/or bothersome to patient.
  • Participants' thyroid nodule must have a TI-RADS rating of 4 or 5.

For full eligibility, visit ClinicalTrials.gov.

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