Cadonilimab in Combination With Bevacizumab and FOLFOX Regimen for the First-Line Treatment of Advanced Unresectable MSS-Type, RAS-Mutated Metastatic Colorectal Cancer

The dual immunotherapy regimen significantly outperformed previous chemotherapy or immunomonotherapy for MSS type advanced CRC in two key efficacy indicators, ORR and PFS. Researchers have also conducted in-depth analysis of patient transcriptomics, immune microenvironment characteristics, and other related information, which is expected to guide more accurate immune combination therapy for CRC in the future. Our team plans to conduct a multicenter, prospective, single arm clinical trial in patients with RAS mutant MSS unresectable metastatic colorectal cancer, with a focus on observing the 1-

Trial Details

NCT ID

NCT06218810

Phase

PHASE2

Sponsor

Fudan University

Status

RECRUITING

Cancer Type

Colon Cancer Colorectal Cancer

Interventions

• Cadonilimab + bevacizumab + FOLFOX

Locations (sample)

• Shanghai, China|31.22222,121.45806

Key Eligibility Criteria

• Voluntarily sign a written ICF.
• Age at enrollment: ≥ 18 years old, ≤ 75 years old, both male and female.
• The Eastern Cancer Collaborative Organization (ECOG) has a physical fitness score of 0 or 1.
• The expected survival period is ≥ 3 months.

For full eligibility, visit ClinicalTrials.gov.

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