Localized Treatment Versus Palliative Chemotherapy in CRC Patients With 10 or More CRLM

The goal of this clinical trial is to investigate the effectiveness of localized interventions in improving the 5-year survival rate for colorectal cancer patients with ≥10 liver metastases. We aim to answer the following question: Can localized interventions, including surgery and/or ablation and/or stereotactic body radiotherapy (SBRT), enhance the 5-year survival rate compared to palliative chemotherapy alone in patients with ≥10 colorectal liver metastases (CRLM)? Participants in this study, who have achieved disease control through chemotherapy, will undergo either localized interventio

Trial Details

NCT ID

NCT06208371

Phase

PHASE3

Sponsor

Sun Yat-sen University

Status

RECRUITING

Cancer Type

Colorectal Cancer

Interventions

Surgical resection and/or ablation therapy and/or SBRT
Palliative Chemotherapy

Locations (sample)

Guangzhou, Guangdong, China|23.11667,113.25

Key Eligibility Criteria

Age ≥ 18 years.
Histologically confirmed colorectal adenocarcinoma.
Baseline imaging (CT, MRI, or PET/CT as necessary) or pathological confirmation of liver metastasis, with no extrahepatic metastasis (consideration…
Disease control (PR or SD) achieved after a minimum of 8 cycles of systemic chemotherapy.

For full eligibility, visit ClinicalTrials.gov.

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