A Retrospective and Prospective Real-world Study of Molecular Typing in the Treatment of Advanced Thyroid Cancer

This is a retrospective and prospective real-world clinical study of molecular typing in the treatment of advanced thyroid cancer. The retrospective study : Patients with advanced thyroid cancer who received precise treatment in the 24 participated hospitals from January 2020 to December 2023 were retrieved. The number of previous treatment lines was not limited. Patients who met the inclusion criteria were screened according to the inclusion and exclusion criteria. Demographic information, clinical characteristics, tumor treatment history, medication regimen, adverse reactions, molecular tes

Trial Details

NCT ID
NCT06195228
Phase
PHASE4
Sponsor
Fudan University
Status
RECRUITING
Cancer Type
Medullary Thyroid Cancer
Interventions
  • dabrafenib plus trametinib with or without PD-1 antibody
  • entrectinib or larotrectinib with or without anti-PD-1 antibdoy
  • pralsetinib or selpercatinib with or without anti-PD-1 antibdoy
  • anlotinib or anlotinib plus anti-PD-1 antibody
  • lenvatinib plus anti-PD-1 antibody
  • Other Targets: precise treatment based on the target
Locations (sample)
  • Fuzhou, Fujian, China|26.06139,119.30611
  • Zhengzhou, Henan, China|34.75778,113.64861
  • Wuhan, Hubei, China|30.58333,114.26667
  • Hohhot, Inner Mongolia, China|40.81056,111.65222
  • Shanghai, Shanghai Municipality, China|31.22222,121.45806

Key Eligibility Criteria

  • Patients volunteered to participate in this study and signed informed consent;
  • Each center can be enrolled in patients who meet the age of their own practice range, regardless of gender ;
  • Histologically diagnosed locally advanced or recurrent / metastatic thyroid cancer that cannot undergo radical surgery meets one of the following r…
  • Radioiodine-refractory differentiated thyroid cancer (RAIR-DTC);

For full eligibility, visit ClinicalTrials.gov.

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