Phase II Clinical Trial to Evaluate the Safety and Efficacy of TQB2450 Injection Combined With Anlotinib Capsule and Chemotherapy in the Treatment of Immunoresistant Advanced Non-small Cell Lung Cancer

Objective to compare the efficacy and safety of TQB2450 injection combined with anlotinib and chemotherapy, and TQB2450 injection combined with chemotherapy in the treatment of advanced non-small cell lung cancer subjects who failed to receive first-line chemotherapy combined with immunization, and to explore and evaluate biomarkers related to efficacy, mechanism of action / resistance mechanism, and safety.

Trial Details

NCT ID
NCT06141226
Phase
PHASE2
Sponsor
Tianjin Medical University Cancer Institute and Hospital
Status
RECRUITING
Cancer Type
Lung Cancer
Interventions
  • TQB2450 +Anlotinib+Docetaxel
  • TQB2450 +Androtinib Placebo+Docetaxel
Locations (sample)
  • Huizhou, Guangdong, China|23.11147,114.41523
  • Nanyang, Henan, China|33.00524,112.54659
  • Lianyungang, Jiangsu, China|34.59845,119.21556
  • Weihai, Shandong, China|37.50914,122.11356
  • Tianjin, Tianjin Municipality, China|39.14222,117.17667

Key Eligibility Criteria

  • According to the International Association for the Study of Lung Cancer and the Joint Committee on the American Classification of Cancer, 8th editi…
  • 18 years old ≤ age ≤ 75 years old; No gender limit; ECOG score 0-1 points; The expected survival period is ≥ 3 months.
  • According to RECIST 1.1 standard, there should be at least one measurable lesion.
  • Tumor resistance has progressed after receiving first-line treatment with immune checkpoint inhibitors (including PD-1 or PD-L1 monoclonal or dual …

For full eligibility, visit ClinicalTrials.gov.

Check If You May Be Eligible

Trialify translates complex eligibility criteria into plain yes-or-no questions to help you understand if this trial might be right for you.

Find Lung Cancer Trials on Trialify →