A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors

This clinical trial is studying advanced solid tumors. Solid tumors are cancers that start in a part of your body like your lungs or liver instead of your blood. Once tumors have grown bigger in one place but haven't spread, they're called locally advanced. If your cancer has spread to other parts of your body, it's called metastatic. When a cancer has gotten so big it can't easily be removed or has spread to other parts of the body, it is called unresectable. These types of cancer are harder to treat. Participants in this study must have cancer that has come back or did not get better with t

Trial Details

NCT ID
NCT06131840
Phase
PHASE1
Sponsor
Seagen, a wholly owned subsidiary of Pfizer
Status
RECRUITING
Cancer Type
Adenocarcinoma Lung Cancer
Interventions
  • PF-08046050
  • bevacizumab
  • 5-Fluorouracil (5-FU)
  • Oxaliplatin
  • Leucovorin (LV)
Locations (sample)
  • Phoenix, Arizona, United States|33.44838,-112.07404
  • Scottsdale, Arizona, United States|33.50921,-111.89903
  • Duarte, California, United States|34.13945,-117.97729
  • Duarte, California, United States|34.13945,-117.97729
  • Aurora, Colorado, United States|39.72943,-104.83192

Key Eligibility Criteria

  • Tumor type:
  • Participants in Part A (dose escalation) and Part B (dose optimization) must have histologically- or cytologically-confirmed metastatic or unresect…
  • Participants in Part A must have one of the following tumor types: colorectal cancer (CRC); gastric carcinoma (GC) or gastroesophageal junction ade…
  • The tumor types to be enrolled in Part B will be identified by the sponsor from among those specified in Part A.

For full eligibility, visit ClinicalTrials.gov.

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