DCIS: RECAST Trial Ductal Carcinoma In Situ: Re-Evaluating Conditions for Active Surveillance Suitability as Treatment

The goal of this trial is to see if active surveillance monitoring and hormonal therapy in patients diagnosed with ductal cell carcinoma in situ (DCIS), an early stage of breast cancer, can be an effective management of the disease. Participants will be asked to receive control hormonal therapy or an investigational hormonal therapy treatment. Participants will be asked to return for evaluation with MRI at three months and six months. Depending on the evaluation participants will have the option to continue on the treatment. If the evaluation suggests surgery is recommended, the participant w

Trial Details

NCT ID
NCT06075953
Phase
PHASE2
Sponsor
QuantumLeap Healthcare Collaborative
Status
RECRUITING
Cancer Type
Lobular Carcinoma Breast Cancer
Interventions
  • Tamoxifen
  • Exemestane
  • Letrozole
  • Anastrazole
  • Testosterone + Anastrazole
  • Elacestrant
Locations (sample)
  • Berkeley, California, United States|37.87159,-122.27275
  • Duarte, California, United States|34.13945,-117.97729
  • Irvine, California, United States|33.66946,-117.82311
  • Los Angeles, California, United States|34.05223,-118.24368
  • San Francisco, California, United States|37.77493,-122.41942

Key Eligibility Criteria

  • A. Female, at least 18 years old
  • B. Previous diagnosis of HR+ DCIS (at least 50% ER or PR; biopsy will have been performed previously at diagnosis) with or without microinvasion
  • C. Patients who have previously received endocrine therapy should have a washout period of 4-6 weeks prior to the screening MRI on the RECAST-DCIS …
  • D. Bilateral mammogram performed within up to 4 months (120 days) of the start of trial treatment may be used for screening evaluation

For full eligibility, visit ClinicalTrials.gov.

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