De-Intensification of Postoperative Radiotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck

This randomized, prospective, multicenter phase II/III trial will study the reduction of radiation volume by eliminating radiotherapy (RT) to the elective neck using strictly defined surgical and radio-oncological standards to reduce radiotherapy-related long-term side effects without affecting locoregional control.

Trial Details

NCT ID
NCT06030440
Phase
PHASE2 / PHASE3
Sponsor
University of Erlangen-Nürnberg Medical School
Status
RECRUITING
Cancer Type
Head and Neck Cancer
Interventions
  • Eliminating RT to the elective neck
  • RT standard of care
Locations (sample)
  • Erlangen, Bavaria, Germany|49.59099,11.00783

Key Eligibility Criteria

  • Histologically proven squamous cell carcinoma of the oral cavity/larynx/oro-or hypopharynx (except glottis cancer (pT1/2pN0))
  • Surgery of primary tumor and neck dissection performed according to predefined surgical standard
  • Indication for postoperative radio(chemo)therapy
  • No lymph node metastases \> 6cm

For full eligibility, visit ClinicalTrials.gov.

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