Testing the Addition of BMS-986016 (Relatlimab) to the Usual Immunotherapy After Initial Treatment for Recurrent or Metastatic Nasopharyngeal Cancer

This phase II trial tests the addition of BMS-986016 (relatlimab) to the usual immunotherapy after initial treatment for nasopharyngeal cancer that has come back after a period of improvement (recurrent) or that has spread from where it first started (primary site) to other places in the body (metastatic). Relatlimab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. The usual approach of treatment is initial treatment with chemotherapy such as the combination of cisplatin (or carboplatin) and gemcitabine, along with immunotherapy such as nivolumab.

Trial Details

NCT ID
NCT06029270
Phase
PHASE2
Sponsor
National Cancer Institute (NCI)
Status
RECRUITING
Cancer Type
Head and Neck Cancer
Interventions
  • Biospecimen Collection
  • Bone Scan
  • Carboplatin
  • Cisplatin
  • Computed Tomography
  • Gemcitabine
Locations (sample)
  • Dublin, California, United States|37.70215,-121.93579
  • Fremont, California, United States|37.54827,-121.98857
  • Fresno, California, United States|36.74773,-119.77237
  • Fresno, California, United States|36.74773,-119.77237
  • Los Angeles, California, United States|34.05223,-118.24368

Key Eligibility Criteria

  • PRIOR TO STEP 1 REGISTRATION:
  • Pathologically (histologically or cytologically) proven diagnosis of nasopharyngeal carcinoma (NPC) that has recurred locoregionally and/or is pres…
  • Tumor showing (histological/cytological) Epstein-Barr encoded ribonucleic acid (EBER)-positivity (e.g., In situ hybridization, immunohistochemistry…
  • A known history of detectable plasma EBV DNA (via a polymerase chain reaction \[PCR\]-based assay) at any time point since the initial diagnosis of…

For full eligibility, visit ClinicalTrials.gov.

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