A Study to Evaluate Pre-operative HYPOfractionated Radiation Therapy in Aged (≥ 70 Years Old) or "Fragile" (≥ 65 Years) Patients With Limb or Trunk Soft Tissue SARComa.

This is a phase II, multicenter, non-randomized study. The main objective is to evaluate the treatment with hypofractionated radiation therapy in neo-adjuvant situations on wound healing in a population of aged patients (≥ 70 years old) or ≥ 65 years of age defined as "fragile" and treated for soft tissue sarcoma. A maximum of 48 evaluable patients will be included in this study. The patients will receive an hypofractionated radiation therapy prior to conservative surgery. Each patient will be followed for up to 3 years after the end of complete treatment (radiotherapy + surgery).

Trial Details

NCT ID

NCT06022159

Phase

PHASE2

Sponsor

Institut Claudius Regaud

Status

RECRUITING

Cancer Type

Sarcoma

Interventions

Hypofractionated Radiation Therapy
Conservative treatment

Locations (sample)

Bordeaux, France|44.84124,-0.58046
Lille, France|50.63391,3.05512
Limoges, France|45.83362,1.24759
Lyon, France|45.74906,4.84789
Montpellier, France|43.61093,3.87635

Key Eligibility Criteria

Patient with histologically confirmed soft tissue sarcoma of the limbs or trunk.
Indication for neo-adjuvant or adjuvant radiotherapy.
Patient aged ≥ 70 years with a performance status ECOG ≤ 2 and/or aged 65 to 70 years with an ECOG of 2 and identified by the investigator as "frag…
Patient affiliated to a Social Health Insurance in France.

For full eligibility, visit ClinicalTrials.gov.

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