A Study of Chlorophyllin for the Management of Brain Radio-necrosis in Patients With Diffuse Glioma

Diffuse gliomas are common tumors involving the brain. They are usually treated by surgery followed by radiation and chemotherapy. Radiotherapy is used for the treatment of brain tumors which causes damage to the tumor cells. However, radiotherapy can also affect the surrounding healthy cells in the brain, causing inflammation and swelling in the region, which is known as radio necrosis (RN). This is considered a late side effect of radiation and is seen in 10-25% of patients treated with radiation for brain tumors. Sometimes, radionecrosis can be detected on routine imaging during follow-up w

Trial Details

NCT ID

NCT06016452

Phase

PHASE2

Sponsor

Tata Memorial Centre

Status

RECRUITING

Cancer Type

Glioblastoma (GBM) Brain Cancer

Interventions

• Chlorophyllin

Locations (sample)

• Mumbai, Maharashtra, India|19.07283,72.88261

Key Eligibility Criteria

• Histological diagnosis of diffuse glioma.
• Radionecrosis on imaging with new neurological symptoms/ worsening of prior deficits (Stratum A) or
• without new symptoms (Stratum B).
• Karnofsky Performance Scale (KPS) ≥ 50.

For full eligibility, visit ClinicalTrials.gov.

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