A Study Assessing KB707 for the Treatment of Locally Advanced or Metastatic Solid Tumors

KB707-01 is a Phase 1/2, open-label, multicenter, dose escalation and expansion study. The study will evaluate the safety and tolerability of KB707 in adults with locally advanced or metastatic solid tumors who have progressed on standard of care therapy, cannot tolerate standard of care therapy, refused standard of care therapy, or for whom there is no standard of care therapy as well as the safety, tolerability, preliminary efficacy, and immunologic effect of KB707 administered in combination with Opdualag to subjects with unresectable or metastatic melanoma. Subjects in dose escalation (Co

Trial Details

NCT ID
NCT05970497
Phase
PHASE1 / PHASE2
Sponsor
Krystal Biotech, Inc.
Status
RECRUITING
Cancer Type
Melanoma
Interventions
  • KB707
  • Opdualag
  • KEYTRUDA ®( Pembrolizumab)
Locations (sample)
  • Los Angeles, California, United States|34.05223,-118.24368
  • Rancho Santa Margarita, California, United States|33.64086,-117.6031
  • Weston, Florida, United States|26.10037,-80.39977
  • Indianapolis, Indiana, United States|39.76838,-86.15804
  • Detroit, Michigan, United States|42.33143,-83.04575

Key Eligibility Criteria

  • Life expectancy \>12 weeks
  • ECOG performance status of 0 or 1
  • Have measurable disease per RECIST v1.1 at Screening
  • Cohorts 1-4 only: Histologically confirmed diagnosis of a locally advanced or metastatic solid tumor and the individual has progressed on standard …

For full eligibility, visit ClinicalTrials.gov.

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