HN-QUEST: A Study of Head and Neck Imaging Biomarkers

This is a multi arm, single center, investigator initiated study to investigate online adaptive radiotherapy and biomarker development in patients with newly diagnosed HNSCC (Head and Neck Squamous Cell Carcinoma) receiving curative therapy. The study will consist of two prospective arms. In Arm 1 up to 100 HNSCC patients receiving (CT)RT (computed tomography-based radiation therapy) will receive up to weekly non-contrast MRI (magnetic resonance imaging) scans during treatment. Arm 2 consists of two cohorts. In cohort A up to 20 healthy volunteers will undergo non-contrast MRI at two time poi

Trial Details

NCT ID

NCT05919290

Phase

NA

Sponsor

University Health Network, Toronto

Status

RECRUITING

Cancer Type

Head and Neck Cancer

Interventions

• MRI

Locations (sample)

• Toronto, Ontario, Canada|43.65333,-79.38389

Key Eligibility Criteria

• Age \>/= 18 years
• Histologically proven Head and Neck Squamous Cell carcinoma
• Primary or nodal disease \> 3cm for biomarker imaging
• Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2

For full eligibility, visit ClinicalTrials.gov.

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