Uterine Preservation Via Lifestyle Transformation

Up to 60% of endometrial cancer cases are attributed to obesity, in part because obesity promotes development of atypical endometrial hyperplasia (AEH), and up to 40% of women with AEH go on to develop endometrial cancer. The increasing prevalence of obesity in premenopausal women has resulted in increasing rates of AEH in this age group. Hysterectomy with removal of the fallopian tubes and ovaries is 100% effective in preventing endometrial cancer, but this approach results in infertility. Fertility-sparing treatments exist, such as treatment with oral or intrauterine progestin, but these tre

Trial Details

NCT ID
NCT05903131
Phase
PHASE2
Sponsor
Washington University School of Medicine
Status
RECRUITING
Cancer Type
Uterine Cancer
Interventions
  • Telemedicine behavioral weight intervention
  • Progestin
  • Enhanced usual care
  • Levonorgestrel-releasing IUD.
Locations (sample)
  • St Louis, Missouri, United States|38.62727,-90.19789
  • Albuquerque, New Mexico, United States|35.08449,-106.65114
  • Oklahoma City, Oklahoma, United States|35.46756,-97.51643

Key Eligibility Criteria

  • Diagnosis of histologically confirmed complex atypical endometrial hyperplasia (AEH) or grade 1 endometrial cancer.
  • Patients with a previous diagnosis of AEH or grade 1 endometrial cancer who are already being followed with conservative management with oral or LN…
  • For patients with a previous diagnosis of AEH or grade 1 endometrial cancer who have been placed on progestin prior to study entry, the duration of…
  • Premenopausal woman with a uterus.

For full eligibility, visit ClinicalTrials.gov.

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