Implantation of iodine125-Seeds Combined With Chemotherapy in the Treatment of Metastatic Pancreatic Carcinoma

The goal of this clinical trial is to evaluate the clinical efficacy and safety of endoscopic ultrasonography (EUS)-guided radioactive iodine 125 seeds in combination with AG regimen chemotherapy for the treatment of metastatic pancreatic cancer. The main questions it aims to answer are: * whether the combination of minimally invasive endoscopy-guided local radiation therapy with chemotherapy may improve overall survival * the adverse events of the combination therapy Participants will receive the implantation of radioactive seeds under EUS guide. 48h after implantation, chemotherapy with Gem

Trial Details

NCT ID
NCT05869474
Phase
NA
Sponsor
Changhai Hospital
Status
RECRUITING
Cancer Type
Pancreatic Cancer
Interventions
  • Iodine125-Seeds implantation
  • Gem/nab-P Chemotherapy
Locations (sample)
  • Shanghai, Shanghai Municipality, China|31.22222,121.45806

Key Eligibility Criteria

  • (Before the trial, subjects must meet all of the requirements listed below in order to be enrolled)
  • 18 to 80 years old;
  • Stage IV pancreatic ductal adenocarcinoma with distant metastases confirmed by clinical, imaging, and pathology, and the primary and metastatic mas…
  • No treatment history of chemotherapy, radiotherapy, or surgery

For full eligibility, visit ClinicalTrials.gov.

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