Impact of Hypofractionated Radiotherapy Strategy After Surgery of Skin Carcinomas in Older Patients

Non-melanoma skin cancer (NMSC) incidence as well as morbidity rates are high in older patients. Surgery is the standard of care. About 5 to 10% of NMSC present high-risk clinico-pathologic features that can increase risk of local recurrence (LR). Adjuvant radiation therapy (ART) is often discussed regarding the risk of local recurrence. Despite the lack of high level evidence, ART is indicated in patients according to unfavorable prognostic factors. ART benefit is generally questioned in regard to the potential degradation of the patient's quality of life (QoL). Currently there is no prospec

Trial Details

NCT ID
NCT05794035
Phase
NA
Sponsor
Assistance Publique - Hôpitaux de Paris
Status
RECRUITING
Cancer Type
Melanoma
Interventions
  • Surgery with additional moderate hypofractionation RT (15 fractions)
  • Surgery alone, without radiation post surgery
  • Surgery with extreme hypo fractionation treatment (HF)
Locations (sample)
  • Créteil, France|48.79266,2.46569

Key Eligibility Criteria

  • Patients aged ≥ 70 years
  • Pathology confirmation of invasive SCC or BCC
  • At least one of high-risk factors for recurrence (R0 but close margins, location/size, microscopic perineural invasion, recurrent primary disease, …
  • No indication of regional nodal RT

For full eligibility, visit ClinicalTrials.gov.

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