Standard Versus Prolonged Antibiotic Prophylaxis After Pancreatoduodenectomy (SPARROW)

The goal of this multicenter randomized controlled trial is to evaluate the additional value of pre-emptive antibiotic treatment on clinically relevant organ/space surgical site infections (OSIs) in patients undergoing pancreatoduodenectomy with a high risk for contaminated bile. The main objectives it aims to answer are: * To evaluate the effect of pre-emptive antibiotic prophylaxis on clinically relevant OSIs in patients undergoing pancreatoduodenectomy with a high risk for contaminated bile * To evaluate the effect of pre-emptive antibiotic prophylaxis on other postoperative outcomes (e.g.

Trial Details

NCT ID

NCT05784311

Phase

PHASE4

Sponsor

Leiden University Medical Center

Status

RECRUITING

Cancer Type

Pancreatic Cancer

Interventions

Cefuroxime
Metronidazole

Locations (sample)

Leiden, South Holland, Netherlands|52.15833,4.49306
's-Hertogenbosch, Netherlands|51.69917,5.30417
Amsterdam, Netherlands|52.37403,4.88969
Breda, Netherlands|51.58656,4.77596
Eindhoven, Netherlands|51.44083,5.47778

Key Eligibility Criteria

Patients undergoing elective pancreatoduodenectomy with a high risk for contaminated bile defined as patients with preoperative biliary drainage or…
Age \>18 years

For full eligibility, visit ClinicalTrials.gov.

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