FUS Etoposide for DMG

The blood brain barrier (BBB) prevents some drugs from successfully reaching the target tumor. Focused Ultrasound (FUS) using microbubbles and neuro-navigator controlled sonication is a non-invasive method of temporarily opening up the blood brain barrier to allow a greater concentration of the drug to reach into the brain tumor. This may improve response and may also reduce system side effects in the patient. The primary purpose of this study is to evaluate the feasibility of safely opening the blood brain barrier in children with progressive diffuse midline gliomas (DMG) treated with oral e

Trial Details

NCT ID
NCT05762419
Phase
PHASE1
Sponsor
Columbia University
Status
RECRUITING
Cancer Type
Brain Cancer
Interventions
  • Etoposide; Oral, 50 Mg
  • Focused ultrasound with neuro-navigator-controlled sonication
Locations (sample)
  • New York, New York, United States|40.71427,-74.00597

Key Eligibility Criteria

  • Ages 4 - 21 years
  • Radiological diagnosis of Diffuse Midline Glioma with tumor involving the pons (intrinsic, pontine based infiltrative lesion; hypointense on T1 wei…
  • Lansky performance status score of at least 60 for subjects 16 years of age or younger.
  • Karnofsky performance status of at least 60 for subjects greater than 16 years of age

For full eligibility, visit ClinicalTrials.gov.

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