A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple Myeloma

This study is researching an experimental drug called linvoseltamab, also called REGN5458. Linvoseltamab has previously been studied by itself (without other cancer drugs) in participants who had advanced multiple myeloma that returned and needed to be treated again after many other therapies had failed. These participants were no longer benefiting from standard medications and had no good treatment options. In that study, some participants who were treated with linvoseltamab had improvement of their myeloma (shrinkage of their tumors), including some participants who had complete responses (

Trial Details

NCT ID
NCT05730036
Phase
PHASE3
Sponsor
Regeneron Pharmaceuticals
Status
RECRUITING
Cancer Type
Relapsed/Refractory Multiple Myeloma
Interventions
  • Linvoseltamab
  • Elotuzumab
  • Pomalidomide
  • Dexamethasone
Locations (sample)
  • Los Angeles, California, United States|34.05223,-118.24368
  • Gainesville, Florida, United States|29.65163,-82.32483
  • Lexington, Kentucky, United States|37.98869,-84.47772
  • Louisville, Kentucky, United States|38.25424,-85.75941
  • Stony Brook, New York, United States|40.92565,-73.14094

Key Eligibility Criteria

  • Age 18 years or older (or legal adult age in the country) at the time of the screening visit.
  • Eastern Cooperative Oncology Group (ECOG) performance status ≤1. Patients with ECOG 2 solely due to local symptoms of myeloma (eg. pain) may be all…
  • Received at least 1 and no more than 4 prior lines of anti-neoplastic MM therapies, including lenalidomide and a proteasome inhibitor and demonstra…
  • Note: Participants in Israel also must have previously received a CD38 antibody. Participants in the EU and the UK must have previously received 2 …

For full eligibility, visit ClinicalTrials.gov.

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