Multiparametric Imaging-based Intraoperative Navigation for Guidance of Surgical Resection and Postoperative Radiotherapy in Patients With Head-and-neck Tumors

The overarching goal of the NAVIGATORR trial is the improvement of local tumor control in head-and-neck cancer (HNC) by increasing the precision of surgical resection and individualization of radiotherapy. Squamous cell carcinomas (SCC) together with salivary gland carcinomas (adenoid cysytic Carcinoma (ACC), mucoepidermoid Carcinoma (MEC), adenocarcinoma (AC)) represent the most common entities in German head and neck oncology. In localized tumors, primary tumor resection with possible adjuvant (chemo)radiotherapy is still the treatment of choice. Advances in targeted therapy and immunotherap

Trial Details

NCT ID
NCT05671458
Phase
NA
Sponsor
Juergen Debus
Status
RECRUITING
Cancer Type
Salivary Gland Head and Neck Cancer
Interventions
  • intraoperative navigation and creation of tumor resection maps
Locations (sample)
  • Heidelberg, Germany|49.40768,8.69079

Key Eligibility Criteria

  • Diagnosis of a malignancy (squamous cell carcinoma (SCC), adenocarcinoma (AC), mucoepidermoid carcinoma (MEC), adenoidcystic carcinoma (ACC)) of th…
  • Indication of surgical tumor resection according to multidisciplinary tumor conference
  • Probably indication for postoperative radiotherapy (e.g. T3/4 tumor)
  • Medical operability and written informed consent of the patient to undergo surgical resection (as indicated clinically)

For full eligibility, visit ClinicalTrials.gov.

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