Hemithyroidectomy or Total-Thyroidectomy in 'Low-risk' Thyroid Cancers

This is a multi-centre, randomised, non-inferiority, phase III study in patients with low risk differentiated thyroid cancer. Patients will be identified via oncology multidisciplinary team meetings. There will be two sources of patients in the trial, with the same histological diagnoses and prognosis (i.e. recurrence risk): * Group 1: Patients who have already had a HT for thyroid problems and are then subsequently diagnosed with low risk DTC will be randomised 1:1 to undergo surveillance only OR a second operation to remove the rest of their thyroid gland (two-stage total thyroidectomy). *

Trial Details

NCT ID
NCT05604963
Phase
NA
Sponsor
University College, London
Status
RECRUITING
Cancer Type
Thyroid Cancer
Interventions
  • Total Thyroidectomy
  • Hemithyroidectomy
Locations (sample)
  • Crewe, Cheshire, United Kingdom|53.09787,-2.44161
  • Bath, United Kingdom|51.3751,-2.36172
  • Birmingham, United Kingdom|52.48142,-1.89983
  • Bristol, United Kingdom|51.45523,-2.59665
  • Cambridge, United Kingdom|52.2,0.11667

Key Eligibility Criteria

  • Aged 16 or over
  • Papillary thyroid cancer:
  • pT1b-2 (≤4cm) irrespective of molecular genetic markers
  • R0 resection (clinically excised but microscopic R1 resected tumours at discretion of the local MDT)

For full eligibility, visit ClinicalTrials.gov.

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