Partial Breast Re-irradiation Using Ultra Hypofractionation (PRESERVE)

Breast-conserving surgery followed by re-irradiation with partial breast irradiation (rPBI) has recently been found to be a safe alternative to mastectomy for women who have undergone prior whole breast radiation. By reducing the volume of tissue receiving radiation, rPBI has been associated with less toxicity and improved cosmetic outcomes. For many women with early-stage breast cancer, shorter 1-week (5-fraction) courses of breast radiation (ultra-fractionation) have been found to be equivalent to longer fractionation schedules in the upfront treatment setting. These 1-week schedules are mor

Trial Details

NCT ID
NCT05592938
Phase
NA
Sponsor
University Health Network, Toronto
Status
RECRUITING
Cancer Type
Breast Cancer
Interventions
  • rPBI
Locations (sample)
  • New York, New York, United States|40.71427,-74.00597
  • New York, New York, United States|40.71427,-74.00597
  • Richmond, Virginia, United States|37.55376,-77.46026
  • Melbourne, Victoria, Australia|-37.814,144.96332
  • São Paulo, São Paulo, Brazil|-23.5475,-46.63611

Key Eligibility Criteria

  • Age \> 18 years
  • In-breast recurrence or new primary (ductal carcinoma in situ (DCIS) or invasive carcinoma)
  • Tumour \<3.0 cm in greatest diameter on pathologic examination, including both invasive and non-invasive components
  • \>5 years after completion of prior adjuvant whole or partial breast radiotherapy (prior nodal radiotherapy permitted)

For full eligibility, visit ClinicalTrials.gov.

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