SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer

This study is being done to answer the following question: Is the chance of cancer spreading or returning the same if radiotherapy to the neck is guided, by using a special imaging study called lymph node mapping (lymphatic mapping) Single Photon Emission Computed Tomography (SPECT-CT), compared to the usual treatment when radiotherapy is given to both sides of the neck?

Trial Details

NCT ID
NCT05451004
Phase
PHASE3
Sponsor
Canadian Cancer Trials Group
Status
RECRUITING
Cancer Type
Head and Neck Cancer
Interventions
  • Lymphatic Mapping with SPECT-CT
  • Ipsilateral and Contralateral Neck
Locations (sample)
  • Corona, California, United States|33.87529,-117.56644
  • Duarte, California, United States|34.13945,-117.97729
  • Irvine, California, United States|33.66946,-117.82311
  • Coral Gables, Florida, United States|25.72149,-80.26838
  • Jacksonville, Florida, United States|30.33218,-81.65565

Key Eligibility Criteria

  • Patients with pathologically proven diagnosis of lateralized OPC (tonsil, tongue base, soft palate, or pharyngeal wall) not involving or crossing m…
  • HPV positive or negative (by p16 immunohistochemistry).
  • Clinical stage T1-3 M0 (UICC/AJCC TNM 8th Edition). Nodal involvement may include no nodes or single or multiple ipsilateral lymph nodes (largest ≤…
  • Radiological investigations within 8 weeks of registration:

For full eligibility, visit ClinicalTrials.gov.

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