A Randomized Trial of Five Fraction Partial Breast Irradiation (RAPID2)

The primary objective of this study is to determine in women with node negative BC ≤3cm in size, if PBI compared to WBI, both given once-a-day over 1 week following BCS, is non-inferior for LR and reduces adverse cosmesis. The primary outcomes are LR and patient-assessed cosmesis at 3 years post randomization.

Trial Details

NCT ID
NCT05417516
Phase
PHASE3
Sponsor
Ontario Clinical Oncology Group (OCOG)
Status
RECRUITING
Cancer Type
Breast Cancer
Interventions
  • Whole Breast Irradiation (WBI)
  • Partial Breast Irradiation (PBI)
Locations (sample)
  • Darlinghurst, New South Wales, Australia|-33.87939,151.21925
  • Hurstville, New South Wales, Australia|-33.9677,151.10149
  • North Sydney, New South Wales, Australia|-33.839,151.2072
  • Bundaberg, Queensland, Australia|-24.86621,152.3479
  • Southport, Queensland, Australia|-27.96724,153.39796

Key Eligibility Criteria

  • For inclusion in this study, patients must fulfill all of the following criteria:
  • Female with a new histological diagnosis of invasive carcinoma of the breast with no evidence of metastatic disease (see AJCC TNM Cancer Staging, A…
  • Treated by BCS with microscopically clear resection margins \>= 1mm for invasive and non-invasive disease or no residual disease on re-excision.
  • Negative axillary node involvement as determined by either sentinel lymph node biopsy or axillary node dissection or clinical assessment with a neg…

For full eligibility, visit ClinicalTrials.gov.

Check If You May Be Eligible

Trialify translates complex eligibility criteria into plain yes-or-no questions to help you understand if this trial might be right for you.

Find Breast Cancer Trials on Trialify →