Cardiac Outcomes With Near-Complete Estrogen Deprivation

The purpose of this research study is to understand what effect near complete estrogen deprivation (NCED) therapy has on the heart in breast cancer patients. Investigators want to understand if NCED changes how the heart works.

Trial Details

NCT ID
NCT05309655
Phase
NA
Sponsor
Duke University
Status
RECRUITING
Cancer Type
Triple Negative (TNBC) Breast Cancer
Interventions
  • Adenosine Stress Cardiac Magnetic Resonance Imaging
  • Electrocardiogram
  • Computed Tomography Angiogram
  • Laboratory Testing
  • Quality of Life Survey
Locations (sample)
  • Durham, North Carolina, United States|35.99403,-78.89862
  • Winston-Salem, North Carolina, United States|36.09986,-80.24422
  • Richmond, Virginia, United States|37.55376,-77.46026

Key Eligibility Criteria

  • Women age ≤55 who were premenopausal at the time of breast cancer diagnosis; (Premenopausal is defined as per NCCN criteria).
  • Planned breast cancer treatment with NCED (near-complete estrogen deprivation) therapy that includes aromatase inhibitor therapy (or SERD) with med…
  • Women with human epidermal growth factor-2 (HER2) negative and women with human epidermal growth factor-2 (HER2) positive breast cancer are eligible.
  • Treatment with CDK-inhibitor, PARP inhibitor immunotherapy or biologic (non-chemotherapy) agent as part of anti-neoplastic treatment plan is allowe…

For full eligibility, visit ClinicalTrials.gov.

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