Spectroscopic MRI, Proton Therapy, and Avastin for Recurrent Glioblastoma

The purpose of this research is to find hidden cancer with an experimental magnetic resonance imaging (MRI) scan called spectroscopic magnetic resonance imaging (sMRI). That spectroscopic MRI scan will be used to increase the area of the brain receiving radiation and then the dose of radiation in attempt to kill more of the cancer. Proton radiotherapy and bevacizumab (Avastin) are used to minimize the possible side effects of this approach.

Trial Details

NCT ID
NCT05284643
Phase
NA
Sponsor
University of Miami
Status
RECRUITING
Cancer Type
Glioblastoma (GBM) Brain Cancer
Interventions
  • Intensity Modulated Proton Therapy (IMPT)
  • Bevacizumab
Locations (sample)
  • Miami, Florida, United States|25.77427,-80.19366

Key Eligibility Criteria

  • A. Recurrent glioblastoma (or variants such as gliosarcoma) based on one of the following criteria:
  • An area of MRI enhancement consistent with glioblastoma outside of the initial high dose radiation field.
  • Biopsy or resection proven recurrent glioblastoma.
  • Progressive glioblastoma based on advanced imaging (brain positron emission tomography (PET), perfusion MRI, or clinical MR Spectroscopy)

For full eligibility, visit ClinicalTrials.gov.

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