Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour

The efficacy of treatment with metformin for promoting cognitive recovery and brain growth in children/adolescents treated for a brain tumour will be investigated in a multi-site Phase III randomized double-blind placebo-controlled parallel arm superiority trial. Specifically, in children/adolescents aged 7 years to 21 years and 11 months who have completed treatment for a brain tumour, is oral administration of metformin for 16 weeks associated with greater improvement of cognitive function and brain growth compared to placebo administered for 16 weeks?

Trial Details

NCT ID
NCT05230758
Phase
PHASE3
Sponsor
Donald Mabbott
Status
RECRUITING
Cancer Type
Brain Cancer
Locations (sample)
  • New Lambton Heights, New South Wales, Australia
  • Westmead, New South Wales, Australia
  • Adelaide, North Adelaide, Australia
  • Clayton, Victoria, Australia
  • Parkville, Victoria, Australia

Key Eligibility Criteria

  • In order to be eligible to participate in this study, an individual must meet all of the following criteria:
  • No less than 3 weeks after completion of:
  • Primary therapy for:
  • medulloblastoma

For full eligibility, visit ClinicalTrials.gov.

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