Modified Sandwich Therapeutic Regimen for Locally Advanced Rectal Cancer

In the treatment of locally advanced rectal cancer, the short-term and long-term efficacy of the traditional sandwich regimen has not reached satisfactory efficacy. For this reason, the concept of reducing the dose of postoperative chemotherapy or directly moving forward the full amount of postoperative chemotherapy was proposed, which is called total neoadjuvant therapy (TNT). However, TNT also includes the high toxicity of oxaliplatin in the whole process and the long time interval between the end of radiotherapy and the operation, which leads to fibrosis of the surrounding tissue, which inc

Trial Details

NCT ID

NCT05228431

Phase

PHASE2

Sponsor

Zhen-Hai Lu

Status

RECRUITING

Cancer Type

Colorectal Cancer

Interventions

XELOX
Capecitabine monotherapy
Radiation

Locations (sample)

Guangzhou, Guangdong, China|23.11667,113.25

Key Eligibility Criteria

Pathological confirmed rectal adenocarcinoma.
Clinical stage T3-4 or T any N1.With or without MRF positivity, with or without EMVI positivity, R0 resection is estimated.
No metastasis
No signs of intestinal obstruction; or intestinal obstruction has been relieved after proximal colostomy surgery.

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