SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

This phase II trial compares the effect of single fraction stereotactic radiosurgery to fractionated stereotactic radiosurgery for the treatment of patients with cancer that has spread to the brain (metastatic brain disease). Stereotactic radiosurgery (SRS) is a form of radiation therapy that focuses high-power energy on a small area of the body. This trial is being done to determine if single (one) fraction stereotactic radiosurgery is better than fractionated stereotactic radiosurgery or vice versa in controlling tumor and side effects in patients with tumors that have spread to the brain.

Trial Details

NCT ID
NCT05222620
Phase
PHASE2
Sponsor
Mayo Clinic
Status
RECRUITING
Cancer Type
Brain Cancer
Interventions
  • Questionnaire Administration
  • Stereotactic Radiosurgery
  • Magnetic Resonance Imaging
Locations (sample)
  • Scottsdale, Arizona, United States|33.50921,-111.89903
  • Jacksonville, Florida, United States|30.33218,-81.65565
  • Albert Lea, Minnesota, United States|43.64801,-93.36827
  • Mankato, Minnesota, United States|44.15906,-94.00915
  • Rochester, Minnesota, United States|44.02163,-92.4699

Key Eligibility Criteria

  • Age \>= 18 years old
  • Presence of presumed brain metastases from an extra-cerebral tumor site (e.g. lung, breast, prostate, etc.)
  • Note: Dural based metastases (e.g. commonly seen in breast cancer) are eligible
  • Size of brain metastases

For full eligibility, visit ClinicalTrials.gov.

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