Medical Imaging and Focused Ultrasound Treatment for Breast Tumors Using Harmonic Motion Imaging (HMI)

This study will investigate Harmonic Motion Imaging guided Focused Ultrasound (HMIgFUS) method for ablation and sonoporation monitoring of breast tumors. The aim of this study is to evaluate the efficacy of real-time guidance/monitoring and ablation/sonoporation method. The hypothesis behind this proposed study is that High Intensity Focused Ultrasound (HIFU) can be used to ablate tumor tissue, and microbubble-mediated Low Intensity Focused Ultrasound (LIFU) can be used to sonoporate tumor vasculature. The investigators of this study also hypothesize that HMI can be used to monitor HIFU ablati

Trial Details

NCT ID
NCT05219695
Phase
PHASE1
Sponsor
Columbia University
Status
RECRUITING
Cancer Type
Breast Cancer
Interventions
  • Harmonic motion imaging guided focused ultrasound (HMIgFUS)
  • Microbubble-mediated Low Intensity Focused Ultrasound (LIFU)
  • Microbubbles
Locations (sample)
  • New York, New York, United States|40.71427,-74.00597

Key Eligibility Criteria

  • Women age 18 years or older with benign tumors or early-stage, non-metastatic breast cancer (stage I without the involvement of axillary lymph nodes)
  • Scheduled to receive surgical resection of the tumor by their clinical care team

For full eligibility, visit ClinicalTrials.gov.

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