Efficacy and Safety of TPIAT for Resectable Adenocarcinoma of the Pancreas Region at High Risk of Postoperative Fistula

Curative management of locally resectable invasive adenocarcinomas located in the cephalic region of the pancreas (pancreas, duodenum and ampulla of Vater) requires a pancreaticoduodenectomy followed by adjuvant chemotherapy. Pancreaticoduodenectomy is a major surgery that often leads to major complications including approximately 20% of relevant clinical postoperative pancreatic fistula. Postoperative complications following pancreaticoduodenectomy can lead to early discontinuation of the complete oncologic strategy, i.e., chemotherapy for malignancy is performed in only about a third of pat

Trial Details

NCT ID
NCT05116072
Phase
PHASE1 / PHASE2
Sponsor
University Hospital, Lille
Status
RECRUITING
Cancer Type
Pancreatic Cancer
Interventions
  • total pancreatectomy
  • intraportal islet autotransplantation
Locations (sample)
  • Lille, France|50.63391,3.05512

Key Eligibility Criteria

  • Inclusion criteria are composed of preoperative conditions validated by intraoperative confirmation to plan an exit of the protocol if the pancreas…
  • Age ≥ 18 years
  • Locale resectable invasive adenocarcinomas located in the cephalic region of the pancreas documented by endoscopic ultrasonography with fine-needle…
  • pancreatic adenocarcinoma;

For full eligibility, visit ClinicalTrials.gov.

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