A Phase 2 Single-Arm Open-Label Pilot Trial Evaluating Zanidatamab (ZW25) in Patients With Early Stage HER2/Neu Positive (HER2+) Breast Cancer (BC)

This is a Phase 2, single-site, single-arm open-label trial of zanidatamab in patients with early stage, low risk HER2+ BC. The primary objective is to determine the efficacy of zanidatamab for patients with early stage HER2/neu positive (HER2+) breast cancer (BC) as determined by pathologic complete response (pCR) .

Trial Details

NCT ID

NCT05035836

Phase

PHASE2

Sponsor

M.D. Anderson Cancer Center

Status

RECRUITING

Cancer Type

HER2 Positive Breast Cancer

Interventions

Zanidatamab
Letrozole
Tamoxifen

Locations (sample)

Houston, Texas, United States|29.76328,-95.36327

Key Eligibility Criteria

Ability to give written informed consent
Age \> 18 years at time of study entry.
Patient would be willing to undergo surgery is appropriate for surgery
Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 (Appendix 1).

For full eligibility, visit ClinicalTrials.gov.

Check If You May Be Eligible

Trialify translates complex eligibility criteria into plain yes-or-no questions to help you understand if this trial might be right for you.

Find HER2 Positive Breast Cancer Trials on Trialify →