TT-10 (PORT-6) and TT-4 (PORT-7) as Single Agents and in Combination in Subjects With Advanced Selected Solid Tumors

The goal of this clinical trial is to evaluate TT-10, TT-4 and TT-10 + TT-4, (Dual Blockade) in participants with advanced selected solid tumors, who have failed or are not eligible for standard of care. The main questions it aims to answer are: 1. To evaluate the safety and tolerability of TT-10, TT-4 and TT-10 + TT-4, (Dual Blockade) 2. To determine the maximum tolerated dose or the recommended phase 2 dose of TT-10, TT-4 and TT-10 + TT-4, (Dual Blockade) 3. To obtain a preliminary estimate of efficacy of TT-10, TT-4 and TT-10 + TT-4, (Dual Blockade) in advanced solid tumors.

Trial Details

NCT ID
NCT04969315
Phase
PHASE1 / PHASE2
Sponsor
Portage Biotech
Status
RECRUITING
Cancer Type
Adenocarcinoma Lung Cancer
Interventions
  • TT-10
  • TT-4
Locations (sample)
  • Los Angeles, California, United States|34.05223,-118.24368
  • Louisville, Kentucky, United States|38.25424,-85.75941
  • Houston, Texas, United States|29.76328,-95.36327

Key Eligibility Criteria

  • Participants must be ≥18 years of age.
  • Participants or their legal representative must be able to provide written informed consent to participate in the study prior to the performance of…
  • Diagnosis of histologically or cytologically confirmed advanced selected solid tumors:
  • Cohort A - TT-10 dose escalation:

For full eligibility, visit ClinicalTrials.gov.

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