Treatment of Newly Diagnosed Patient's With Wilm's Tumor Requiring Abdominal Radiation Delivered With Proton Beam Irradiation

Participants are being asked to take part in this clinical trial, a type of research study, because the participants have a Wilms Tumor cancer. Primary Objectives To determine whether delivery of proton beam radiation to a conformal reduced target volume in the flank allows normal flank growth compared to the contralateral untreated side and non-irradiated patients. Secondary Objectives To deliver proton beam radiation to a conformal reduced target volume (partial kidney proton beam radiation therapy) in the affected kidney(s) for patients with Stage V (bilateral Wilms tumor) and specific

Trial Details

NCT ID
NCT04968990
Phase
PHASE2
Sponsor
St. Jude Children's Research Hospital
Status
RECRUITING
Cancer Type
Kidney Cancer
Interventions
  • Proton Beam Radiation (PBRT)
  • DD-4A Chemotherapy Regimen
  • Complete Surgical Resection
  • Surgical Resection
  • Partial Nephrectomy
Locations (sample)
  • Memphis, Tennessee, United States|35.14953,-90.04898

Key Eligibility Criteria

  • Patients are eligible to be enrolled on this trial at the time of initial (or presumptive) diagnosis of Wilms tumor, at the time of surgery or at t…
  • Patients that are determined to be stage I or II will be eligible for the surgical and biologic aspects of this trial but will otherwise be followe…
  • Patients identified to have an anaplastic or other unfavorable tissue component (non-Wilms histology) to their tumor may have tissue assessed for t…
  • Performance Level • The Karnofsky performance status must be ≥50 for patients \>16 years of age and the Lansky performance status must be ≥ 50 for …

For full eligibility, visit ClinicalTrials.gov.

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