Engineered TILs/CAR-TILs to Treat Advanced Solid Tumors

Tumor infiltration lymphocytes (TILs) have been harvested from advanced cancer patients and constructed to knockout PD1 gene and express scFvs against both PD1 and CTALA4 and CARs against various antigens, followed by transfusion into the patients. The safety, tolerance, and preliminary clinical efficacy of the TILs will be evaluated.

Trial Details

NCT ID
NCT04842812
Phase
PHASE1
Sponsor
Second Affiliated Hospital of Guangzhou Medical University
Status
RECRUITING
Cancer Type
Colorectal Cancer
Interventions
  • TILs and CAR-TILs targeting HER2, Mesothelin, PSCA, MUC1, Lewis-Y, GPC3, AXL, EGFR, Claudin18.2/6, ROR1, GD1, or B7-H3
Locations (sample)
  • Guangzhou, China|23.11667,113.25

Key Eligibility Criteria

  • Patients with advanced cancers that failed to current available therapies;
  • Life expectancy \>12 weeks;
  • Adequate heart, lung, liver, kidney functions;
  • Available for tumor biopsy or cancerous effusions;

For full eligibility, visit ClinicalTrials.gov.

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