Impact of Peri-operative tEstosterone Levels on oNcological and Functional Outcomes in RadiCal prostatEctomy

Sexual dysfunction is a common side effect of radical prostatectomy (RP) and has a significant negative impact on quality of life. With age the testosterone level in men declines; around 30% of men over 70 years of age meet the criteria of testosterone deficiency (TD). The negative impact of both TD and RP on sexual performance are likely to add up. The aim of this study is to assess the efficacy and safety of testosterone replacement therapy (TRT) on functional and oncological outcomes in testosterone deficient men following RP for prostate cancer (PCa).

Trial Details

NCT ID
NCT04833426
Phase
PHASE3
Sponsor
Canisius-Wilhelmina Hospital
Status
RECRUITING
Cancer Type
Prostate Cancer
Interventions
  • Testosterone gel
  • Placebo
Locations (sample)
  • Amsterdam, Netherlands|52.37403,4.88969
  • Amsterdam, Netherlands|52.37403,4.88969
  • Arnhem, Netherlands|51.98,5.91111
  • Eindhoven, Netherlands|51.44083,5.47778
  • Emmen, Netherlands|52.77917,6.90694

Key Eligibility Criteria

  • Men aged 18 years or older
  • Histologically confirmed prostate cancer
  • Radical prostatectomy performed as primary treatment
  • At least one-sided nerve-sparing procedure performed

For full eligibility, visit ClinicalTrials.gov.

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