PRophylactic Cerebral Irradiation or Active MAgnetic Resonance Imaging Surveillance in Small-cell Lung Cancer Patients (PRIMALung Study)

In this phase III study, the primary objective is to test with a one-sided significance of 5% whether for the treatment of small cell lung cancer (SCLC) patients, brain MRI surveillance alone is non-inferior in terms of overall survival compared to prophylactic cranial irradiation (PCI) combined with brain MRI surveillance in the entire study population.

Trial Details

NCT ID
NCT04790253
Phase
NA
Sponsor
European Organisation for Research and Treatment of Cancer - EORTC
Status
RECRUITING
Cancer Type
Brain Cancer
Locations (sample)
  • Graz, Austria
  • Anderlecht, Belgium
  • Edegem, Belgium
  • Kortrijk, Belgium
  • Liège, Belgium

Key Eligibility Criteria

  • Age ≥ 18 years
  • Histologically/cytologically proven diagnosis of SCLC
  • Limited and extensive stage
  • LS SCLC: Stage I-III (T any, N any, M0, according to UICC TNM staging v8.0) that can be safely treated with definitive radiation doses. Excludes T3…

For full eligibility, visit ClinicalTrials.gov.

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