Non-ablative Oligofractionated Radiation Therapy Before Surgical Transplantation As Radiovaccination

This is a prospective phase I study to determine the safety and feasibility of non-ablative oligofractionated radiation therapy (NORT) before lung transplantation for patients with underlying pulmonary malignancy. We hypothesize that heterogeneous dose distributions could generate a vaccination effect against the tumor by creating anti-tumoral immune response in the body and these patients may be immunized against their tumor which could reduce the risk of cancer recurrence after transplantation despite the anti-rejection medications required for the transplantation.

Trial Details

NCT ID
NCT04782752
Phase
NA
Sponsor
Marc de Perrot
Status
RECRUITING
Cancer Type
Lung Cancer
Interventions
  • Radiation: Varying Doses of RT
Locations (sample)
  • Toronto, Ontario, Canada|43.70643,-79.39864

Key Eligibility Criteria

  • Patients with end-stage lung disease and suspected stage I primary lung cancer based on CT and PET scan not accessible to curative treatment, inclu…
  • Patients with multifocal pulmonary malignancy, including multifocal lung adenocarcinoma, not accessible to curative treatment, including surgery an…
  • Patients with isolated metastases in one or both lungs after complete resection of the primary tumor in the absence of other sites of metastatic di…
  • Meet eligibility criteria for lung transplantation with the exception of the underlying malignancy.

For full eligibility, visit ClinicalTrials.gov.

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