Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial

This phase III trial compares minimally invasive surgery (MIS) to laparotomy in treating patients with stage IIIC-IV ovarian, primary peritoneal, or fallopian tube cancer who are receiving chemotherapy before and after surgery (neoadjuvant chemotherapy). MIS is a surgical procedure that uses small incision(s) and is intended to produce minimal blood loss and pain for the patient. Laparotomy is a surgical procedure which allows the doctors to remove some or all of the tumor and check if the disease has spread to other organs in the body. MIS may work the same or better than standard laparotomy

Trial Details

NCT ID
NCT04575935
Phase
PHASE3
Sponsor
M.D. Anderson Cancer Center
Status
RECRUITING
Cancer Type
Ovarian Cancer
Interventions
  • Chemotherapy
  • Laparotomy
  • Minimally Invasive Surgery
  • Quality-of-Life Assessment
  • Questionnaire Administration
Locations (sample)
  • Miami, Florida, United States|25.77427,-80.19366
  • Weston, Florida, United States|26.10037,-80.39977
  • Boston, Massachusetts, United States|42.35843,-71.05977
  • Boston, Massachusetts, United States|42.35843,-71.05977
  • Mineola, New York, United States|40.74927,-73.64068

Key Eligibility Criteria

  • Age ≥ 18 years old
  • Stage IIIC or IV, high-grade (serous, endometrioid, clear-cell, transitional carcinomas), invasive epithelial ovarian carcinoma, primary peritoneal…
  • Patient is considered by treating physician to be a surgical candidate after completion of 3 to 4 cycles of platinum-based chemotherapy, or an inve…
  • Normalization of CA-125 according to individual participating center reference range (Note: Among patients with a normal CA-125 at initiation of th…

For full eligibility, visit ClinicalTrials.gov.

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