Neoadjuvant Upper Tract Invasive Cancer Trial (NAUTICAL)

Upper tract urothelial cancer (UTUC) is cancer in the lining of the kidney or ureter (the tube that drains the kidney). This type of cancer is rare and as a result, there are only a few studies that have looked at it. Standard of care for UTUC would be surgery followed by chemotherapy (adjuvant chemotherapy). However, we know from studies that have looked at cancer of the lining of the bladder, which is a similar cancer in many ways, that treating people with chemotherapy before surgery (neoadjuvant chemotherapy) can lead to longer survival compared to the standard of care. There are no studi

Trial Details

NCT ID
NCT04574960
Phase
PHASE3
Sponsor
University Health Network, Toronto
Status
RECRUITING
Cancer Type
Urothelial Carcinoma Bladder Cancer
Interventions
  • Gemcitabine
  • Cisplatin
  • Carboplatin
Locations (sample)
  • Ottawa, Ontario, Canada|45.41117,-75.69812
  • Toronto, Ontario, Canada|43.70643,-79.39864

Key Eligibility Criteria

  • Newly diagnosed radiographically visible (CT or MRI) cT1-4 N0 M0 with positive selective urinary cytology, positive bladder urinary cytology, or en…
  • Age ≥18 years of age
  • Eastern Cooperative Oncology Group (ECOG) score 0-1
  • Medically appropriate candidate for radical nephroureterectomy or ureterectomy as per participating site attending urologic oncologist

For full eligibility, visit ClinicalTrials.gov.

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