Preoperative Short-Course Radiation Therapy With PROtons Compared to Photons In High-Risk RECTal Cancer (PRORECT)

To investigate a potential toxicity benefit of preoperative radiation therapy with protons compared to conventional photon beam radiation therapy in patients with locally advanced rectal cancer.

Trial Details

NCT ID
NCT04525989
Phase
NA
Sponsor
Alexander Valdman
Status
RECRUITING
Cancer Type
Colorectal Cancer
Interventions
  • Radiation therapy
Locations (sample)
  • Stockholm, Solna, Sweden|59.32938,18.06871
  • Gävle, Sweden|60.67452,17.14174
  • Gothenburg, Sweden|57.70716,11.96679
  • Linköping, Sweden|58.41086,15.62157
  • Lund, Sweden|55.70584,13.19321

Key Eligibility Criteria

  • Inclusion Criteria - Primary tumour characteristics
  • Biopsy-proven, newly diagnosed primary rectal adenocarcinoma, i.e. with the lowest part of the tumour less than 16 cm from the anal verge detected …
  • Locally advanced tumour fulfilling at least one of the following criteria on pelvic MRI indicating high risk of failing locally and/or systemically:
  • Clinical stage (c) T4b, i.e. infiltration of an adjacent organ or structure like the prostate, urinary bladder, uterus, sacrum, pelvic floor or sid…

For full eligibility, visit ClinicalTrials.gov.

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