Study of APG2575 Single Agent and Combination Therapy in Patients With Relapsed/Refractory CLL/SLL

The purpose of this study is to assess the safety, pharmacokinetic, pharmacodynamic and efficacy of APG-2575 single agent and in combination with other therapeutic agents in patients with relapsed/refractory CLL/SLL.

Trial Details

NCT ID
NCT04494503
Phase
PHASE1 / PHASE2
Sponsor
Ascentage Pharma Group Inc.
Status
RECRUITING
Cancer Type
Lymphoma
Interventions
  • APG-2575
  • Rituximab
  • Ibrutinib
Locations (sample)
  • Beijing, Beijing Municipality, China|39.9075,116.39723
  • Chongqing, Chongqing Municipality, China|29.56026,106.55771
  • Guangzhou, Guangdong, China|23.11667,113.25
  • Nanning, Guangxi, China|22.81667,108.31667
  • Guiyang, Guizhou, China|26.58333,106.71667

Key Eligibility Criteria

  • Subjects who meet each of the following inclusion criteria are eligible to participate in this study:
  • Age ≥18 years old.
  • Diagnosis as relapsed/refractory chronic lymphocytic leukemia/ small lymphocytic lymphoma according to the IWCLL NCI-WG guidelines revised in 2008.
  • Through radiological assessment, subjects with a lymph node length ≥ 10 cm require prior approval from the sponsor before enrollment.

For full eligibility, visit ClinicalTrials.gov.

Check If You May Be Eligible

Trialify translates complex eligibility criteria into plain yes-or-no questions to help you understand if this trial might be right for you.

Find Lymphoma Trials on Trialify →