Toripalimab Plus Concurrent Chemo-radiotherapy for Unresectable Locally Recurrent Nasopharyngeal Carcinoma

Through multicenter, open-label, randomised clinical trials, we intend to demonstrate that concurrent and adjuvant PD-1 treatment added to concurrent chemo-radiotherapy could further decrease the rate of disease progression and improve the survival outcome of patients with unresectable locally recurrent nasopharyngeal carcinoma compared with those treated with concurrent chemo-radiotherapy alone.

Trial Details

NCT ID
NCT04453813
Phase
PHASE3
Sponsor
Sun Yat-sen University
Status
RECRUITING
Cancer Type
Nasopharyngeal Head and Neck Cancer
Interventions
  • Toripalimab plus concurrent chemo-radiotherapy
  • Concurrent chemo-radiotherapy
Locations (sample)
  • Guangzhou, Guangdong, China|23.11667,113.25
  • Guangzhou, Guangdong, China|23.11667,113.25
  • Shaoguan, Guangdong, China|24.8,113.58333
  • Zhongshan, Guangdong, China|22.52306,113.37912
  • Zhuhai, Guangdong, China|22.27694,113.56778

Key Eligibility Criteria

  • Histologically confirmed recurrent nasopharyngeal carcinoma.
  • The recurrence time is more than 12 months from the end of the first course of radiotherapy.
  • Tumor staged as rT2-4N0-3M0,rII-IVa (according to the 8th AJCC edition).
  • Subjects must have a measurable disease by CT or MRI per RECIST 1.1 criteria.

For full eligibility, visit ClinicalTrials.gov.

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