Testing Less Intensive Radiation With Chemotherapy to Treat Low-risk Patients With HPV-positive Oropharyngeal Cancer

This trial will explore giving standard dose chemotherapy and radiation therapy to sites of disease including all lymph nodes involved with HPV-positive oropharyngeal cancer, but administer lower doses of radiation therapy to the lymph nodes that are not known to be involved with cancer. By doing so, it is hypothesized that there will be equally good long term loco-regional and distant disease control but will reduced long term treatment side effects and improved quality of life in persons living well beyond their cancer treatment.

Trial Details

NCT ID
NCT04444869
Phase
PHASE2
Sponsor
University of Missouri-Columbia
Status
RECRUITING
Cancer Type
Head and Neck Cancer
Interventions
  • Cisplatin injection
Locations (sample)
  • Columbia, Missouri, United States|38.95171,-92.33407

Key Eligibility Criteria

  • Patients generally must have the psychological ability and general health that permits completion of the study requirements and required follow up.
  • Women of childbearing potential and men who are sexually active should be willing and able to use medically acceptable forms of contraception throu…
  • Pathologically (histologically or cytologically) proven diagnosis of squamous cell carcinoma (including the histological variants papillary squamou…
  • Patients must have clinically or radiographically evident measurable disease at the primary site or at nodal stations. Tonsillectomy or local excis…

For full eligibility, visit ClinicalTrials.gov.

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