Bladder Fiducial Markers and Multiparametric-MRI (Mp-MRI) to Optimize Bladder Chemo-radiotherapy

The purpose of this study is to examine the usefulness of implanting small 24-K gold fiducial markers around a bladder tumor site, so that a Radiation Oncologist can identify the original tumor location at the time of radiation treatment. Other goals of the study include assessing whether a new MRI imaging technology can help with detection of bladder cancer earlier and more accurately when evidence of bladder cancer is not visible by scope.

Trial Details

NCT ID
NCT04442724
Phase
NA
Sponsor
Cedars-Sinai Medical Center
Status
RECRUITING
Cancer Type
Bladder Cancer
Interventions
  • Fiducial marker placement
  • Multiparametric MRI (mpMRI)
Locations (sample)
  • Los Angeles, California, United States|34.05223,-118.24368
  • Los Angeles, California, United States|34.05223,-118.24368
  • Boston, Massachusetts, United States|42.35843,-71.05977

Key Eligibility Criteria

  • Pathologically (histologically or cytologically) proven diagnosis of primary urothelial carcinoma of the bladder. Subjects with mixed histology are…
  • Clinical stage T2-T4a, Nx, M0 considered appropriate for, and electing to receive, chemoradiation of the bladder
  • Planned TURBT as part of the normal course treatment, to take place prior to the initiation of chemo irradiation
  • Adequate renal function: Serum creatinine \< 2 mg/dL OR calculated creatinine clearance (CrCl) \> 30ml/min

For full eligibility, visit ClinicalTrials.gov.

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