A Randomized Controlled Trial Evaluating of Prophylactic Irradiation in CRT for cT1bN0M0 ESCC

This study is conducted to investigate whether modified chemoradiotherapy with elective nodal irradiation reduces the locoregional recurrence that cannot be completely resected by salvage endoscopic resection and preserve esophagus without compromising overall survival.

Trial Details

NCT ID
NCT04328948
Phase
PHASE3
Sponsor
National Cancer Center, Japan
Status
RECRUITING
Cancer Type
Esophageal Cancer
Interventions
  • Chemoradiotherapy
Locations (sample)
  • Tokyo, Japan|35.6895,139.69171

Key Eligibility Criteria

  • Histologically proven squamous cell carcinoma, adenosquamous carcinoma, or basaloid cell carcinoma.
  • All lesions located in the thoracic esophagus. Secondary lesions with an absolute indication for endoscopic resection (EMR/ESD) may not be confined…
  • Clinical N0M0 with cervical to abdominal contrast-enhanced CT.
  • The deepest lesion is diagnosed as cT1b (SM1 / SM2 / SM3) with upper gastrointestinal endoscopy. If it is difficult to differentiate cT1a-MM and cT…

For full eligibility, visit ClinicalTrials.gov.

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