The DBCG Proton Trial: Photon Versus Proton Radiation Therapy for Early Breast Cancer

The majority of early breast cancer patients are treated with adjuvant radiation therapy (RT) as part of their multimodal therapy. The aim of the RT is to lower the risk of local, regional and distant failure and improve survival. Modern RT is been provided with photon therapy. Now, more proton therapy facilities are opened, including in Denmark. Proton RT may have the potential to cause lower dose to heart and lung during breast RT. This trial will randomise patients between standard photon RT versus experimental proton RT. The primary endpoint is 10 year risk of heart disease.

Trial Details

NCT ID
NCT04291378
Phase
NA
Sponsor
Danish Breast Cancer Cooperative Group
Status
RECRUITING
Cancer Type
Breast Cancer
Interventions
  • Proton versus photon radiation therapy
Locations (sample)
  • Aalborg, Denmark|57.048,9.9187
  • Aarhus, Denmark|56.15674,10.21076
  • Copenhagen, Denmark|55.67594,12.56553
  • Copenhagen, Denmark|55.67594,12.56553
  • Herlev, Denmark|55.72366,12.43998

Key Eligibility Criteria

  • Patient operated for early breast cancer with indication for radiation therapy, where standard planning shows a mean heart dose 4 Gy or more and/or…
  • Boost (breast, chest wall and nodal), breast reconstruction (any type, except implants with metal), connective tissue disease, post-operative surgi…
  • Patient with previous non-breast malignancy is accepted if the patient has been without disease minimum 5 years, and the treating oncologist estima…
  • Life expectancy minimum 10 years

For full eligibility, visit ClinicalTrials.gov.

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