Intensive Intraperitoneal Therapy in Advanced Ovarian Cancer

Clinicians postulate that it may be interesting to combine the two IntraPeritoneal (IP) treatments associated with a significant improvement of OC overall survival i.e. cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) and postoperative intraperitoneal chemotherapy (IPC) as an " intensive peritoneal " regimen in the initial management of stages III-IVA ovarian cancers. Performing a postoperative IPC may allow completing and extending the duration of the effect of HIPEC in decreasing the risk of peritoneal recurrence. HIPEC may also allow administering an early IP tre

Trial Details

NCT ID
NCT04282356
Phase
PHASE2
Sponsor
Institut du Cancer de Montpellier - Val d'Aurelle
Status
RECRUITING
Cancer Type
Ovarian Cancer
Interventions
  • Intraperitoneal chemotherapy during surgery
Locations (sample)
  • Montpellier, France|43.61093,3.87635

Key Eligibility Criteria

  • Patients aged 18 to 75 years,
  • Patients with high-grade serous (high grade according to MD Anderson, grade II and III according to Silverman) ovarian or tubal or primitive perito…
  • Initial laparoscopy confirming the histological type, evaluating the extent of the disease by PCI score and confirming the initial non-resectability,
  • Stage III B-C (FIGO 2014) or stage IVA with minimal or moderate pleural effusion (measured on a thoracic CT scanner, the largest thickness of which…

For full eligibility, visit ClinicalTrials.gov.

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